SPATIAL DISTRIBUTION AND PREDICTIVE SIGNIFICANCE OF DENDRITIC CELLS AND MACROPHAGES IN ESOPHAGEAL CANCER TREATED WITH COMBINED CHEMORADIOTHERAPY AND PD-1 BLOCKADE

BackgroundThe first clinical study (NCT03671265) of first-line chemoradiotherapy combined with PD-1 blockade showed promising treatment outcomes in locally advanced esophageal squamous cell carcinoma (ESCC).However, partial patients did not respond to the combination treatment.The roles of dendritic cells (DCs) and macrophages in this combination t

INTRODUCTION: despite the well-known maxim "publish or perish" among academicians, productivity remains low in Nigeria.There are barriers to academic writing which must be identified and addressed.Even after dressing those barriers, authors are faced with another dilemma-where to publish.It was the concern of the authors to evaluate perceived barri

In the context of globalization of society, information becomes not just the sum of knowledge necessary for mankind, but a means of manipulating the consciousness of millions of people, a way of inciting hatred and enmity.Verbal crimes are committed against both human rights and freedoms and against the peace and security of mankind.In recent years

BICD2 is one of the two mammalian homologues of the Drosophila Bicaudal D, an evolutionarily conserved adaptor between microtubule motors and their cargo that was previously shown to link vesicles and mRNP complexes to the dynein Nail Polish motor.Here, we identified a G2-specific role for BICD2 in the relative positioning of the nucleus and centro

Organizing a large volume of scientific multimedia data requires the use of appropriate indexing methods as one of the processes of information organization.Appropriate methods and algorithms are those that lead to the improvement of various aspects of quality in the process of organizing and retrieving information.For this reason, the purpose of t